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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10600 | BRCA1-IN-1 | Others | |
BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM). | |||
T10601 | BRCA1-IN-2 | Others | |
BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins. | |||
T73343 | BAP1-IN-1 | ||
BAP1-IN-1 is a catalytic activity inhibitor of BRCA1 associated protein 1 (BAP1), exhibiting an inhibitory concentration (IC50) ranging between 0.1-1 μM. | |||
T71757 | SC-10914 | ||
SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC5... | |||
T79593 | PARP1-IN-14 | PARP | |
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with ... | |||
T79405 | PARP1-IN-15 | PARP | |
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ... | |||
T83855 | TG2-179-1 | ||
TG2-179-1 is a BRCA1-associated protein 1 (BAP1) inhibitor that effectively hampers BAP1's deubiquitinase activity in cell-free assays at concentrations between 25 µM and 1.5 mM. This compound exhibits cytotoxicity towar... | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d... |